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A German-Iranian national and longtime US resident has been executed in Iran after being convicted of terrorism offences, according to Iranian state media citing the country’s judiciary-affiliated Mizan news agency.

Jamshid Sharmahd, 69, was executed Monday morning for “planning and orchestrating a series of terrorist acts,” state-run IRNA and Press TV reported. His execution sparked condemnation from the United States and Germany.

Sharmahd’s daughter Gazelle has repeatedly said her father is innocent and that he faced a sham trial due to his political activism and criticism of the Islamic Republic.

Sharmahd was arrested in 2020 by Iranian authorities who claimed he headed a group accused of a deadly 2008 bombing in the city of Shiraz, according to state-run news agencies ISNA and IRNA.

He was sentenced to death in 2022 for “corruption on Earth”, sparking widespread condemnation from human rights groups and Western governments.

“He has been sentenced to death after a legal proceeding that has been widely criticized as a sham trial,” Vedant Patel, the US State Department’s principal deputy spokesperson said in a briefing last fall. Amnesty International also described the trial as “grossly unfair.”

Following the news of his execution, German foreign minister Annalena Baerbock said that Sharmahd’s “murder” showed Tehran to be an “inhumane regime” that “uses death as a weapon.”

Baerbock said the execution would have “serious consequences.”

The United States’ Office of the Special Envoy for Iran said it was looking into reports of Sharmahd’s execution and said his killing would “represent the latest abhorrent act in the regime’s long history of transnational repression and accelerating rate of executions.”

Sharmahd’s “kidnapping and rendition, as well as sham trial and reports of torture, were reprehensible,” the envoy’s office added.

Abram Paley, the US Deputy Special Envoy, last year met with Sharmahd’s family to discuss his imprisonment and death sentence.

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Israel’s parliament has voted to ban a nearly eight-decade-old United Nations agency that provides essential services for Palestinian refugees, a move that could have devastating consequences for millions of Palestinians living under Israeli occupation.

On Monday, the Knesset passed two bills; one barring UNRWA from activity within Israel, and another banning Israeli authorities from any contact with UNRWA – revoking the 1967 treaty that allows UNRWA to provide services to Palestinian refugees in areas under Israel’s control.

The move is expected to severely restrict the UN Relief and Works Agency for Palestine Refugees (UNRWA) from operating in territories Israel occupies.

Following the passing of the first law, Boaz Bismuth, a member of Likud, the architect of the bill, said: “Anyone that behaves like a terrorist has no rights in Israel…. UNRWA equals Hamas, period.”

Before the passing of the second law, another member, Yuli Edelstein, claimed the directive “does not in any way harm humanitarian aid to the Gaza Strip” and insisted Israel was acting within the framework of international law.

The move went ahead despite heated opposition from Arab members of the Knesset and strong international pressure from Western nations. The first law was approved with 92 votes in favor, 10 against. The second was approved with 87 votes in favor, 9 against.

Several countries, including the United States, have expressed deep concerns about the controversial ban, which could impact the education, food, healthcare and livelihoods of millions of Palestinians who depend on the agency.

Prior to the vote, the US State Department had urged Israel not to pass the legislation, saying the agency plays “an irreplaceable role right now in Gaza.” Secretary of State Antony Blinken has previously warned Israel that passing the legislation could “have implications under US law and US policy.”

Israel has long sought to dismantle the UN body, arguing that some of its employees are affiliated with Hamas, and that its schools teach hate against Israel. UNRWA has repeatedly denied these accusations, saying there is “absolutely no ground for a blanket description of ‘the institution as a whole’ being ‘totally infiltrated.’”

Here’s what we know about UNRWA, and the implications of the Israeli ban.

What is UNRWA and what does it do?

UNRWA was founded by the United Nations a year after the 1948 creation of Israel that led to the displacement of hundreds of thousands of Palestinians from their homes in an event known by Palestinians as the “Nakba” (catastrophe).

The agency, which began by assisting about 750,000 Palestinian refugees in 1950, now serves some 5.9 million across the Middle East, many of whom live in refugee camps in Jordan, Lebanon, Syria, the Gaza Strip, the West Bank and East Jerusalem.

In the Gaza Strip, which has been ravaged by a devastating Israeli war for more than a year, UNRWA serves some 1.7 million Palestinian refugees. In the West Bank and East Jerusalem, it assists around 871,500 refugees.

The agency provides a wide range of aid and services to Palestinian refugees and their descendants, including shelter, healthcare, food and education. It is also a major source of employment for the refugees, who make up most of its more than 30,000 employees across the Middle East, and has representative offices in New York, Geneva and Brussels.

More than 13,000 of its employees are stationed in Gaza alone. In the West Bank and East Jerusalem, it employs nearly 4,000 workers.

UNRWA is unique in that it is the only UN agency dedicated to a specific group of refugees in specific areas. While its purpose is to support Palestinian refugees, UNRWA does not have a mandate to resettle them

The UN High Commission for Refugees (UNHCR) is the body that is tasked with resettlement of refugees, but its mandate does not extend to areas UNRWA operates in.

Why does Israel want to ban UNRWA?

Israel has long opposed the agency and sought to dismantle it even before October 7 last year, when Hamas-led militants killed 1,200 people in Israel and took more than 250 hostages. Israeli officials have rejected UNRWA’s definition of which Palestinians are eligible for refugee status, arguing that descendants of the 1948 refugees do not qualify and thus don’t have the right to return to their ancestral homes in what is now Israel.

An Israeli member of parliament behind the bills accused UNRWA on Sunday of “educating kids to hate Israel and spreading antisemitism.”

But since the war started, Israel has launched an intense campaign to delegitimize the UN body, including accusing some of UNRWA’s employees of association with Hamas’ attack, alleging they took part in varying capacities.

UNRWA strongly denied the allegations, but several governments, including the US, suspended funding for the agency earlier this year while the allegations were being investigated. In January, the agency terminated the contracts of those Israel named and launched an investigation into its claims. Most nations have since restored funding with the exception of the US, its biggest donor.

UNRWA said that that as of October 20 of this year, 233 of its workers were killed. And last month, the agency said that an UNRWA staffer “was shot and killed on the roof of his home by a sniper during an overnight Israeli military operation” in El Far’a Camp in the occupied West Bank, marking the first time a member of the UN agency was killed in the West Bank in more than 10 years, UNRWA said.

What would the impact of UNRWA’s banning be?

UN Secretary-General António Guterres said earlier this month that “in midst of all the upheaval, UNRWA – more than ever – is indispensable… is irreplaceable.”

The UN chief said he sent a letter to Israeli leader Benjamin Netanyahu, telling him that the proposed bill would “suffocate efforts to ease human suffering and tensions in Gaza, and indeed, the entire Occupied Palestinian Territory.”

“It would be a catastrophe,” Guterres said, “in what is already an unmitigated disaster.”

But his calls appear to have fallen on deaf ears. The UN chief has been declared persona-non-grata, or an unwanted person, by Israel, whose officials have repeatedly accused Guterres of being sympathetic to Israel’s adversaries.

UNRWA is the primary humanitarian aid group in Gaza. Nearly 2 million Gazans rely on the agency for aid, with 1 million people using UNRWA shelters for food and healthcare in the enclave. The agency has provided Gazans with everything from food and healthcare to education and psychological support for decades.

Along with the Palestinian Red Crescent, UNRWA handles almost all distribution of UN aid coming into the territory. The agency has 11 food distribution centers for 1 million people in Gaza, more than half of whom UNRWA assesses to live below the abject poverty line of US$ 1.74 per person per day.

The agency has also helped implement an emergency polio vaccination campaign in Gaza, alongside other UN bodies, in a bid to stop the infectious virus that can cause paralysis from spreading. Last week, the third phase of the polio vaccination campaign in Gaza was postponed due to escalating violence in north Gaza, the World Health Organization (WHO) said.

In the West Bank, UNRWA provides services for 19 refugee camps, more than 90 schools and a number of health services, including prenatal care. It distributes basic food supplies, loans, as well as emergency cash grants and shelter, according to the agency’s website.

It is unclear who would assume assistance for the millions of Palestinian refugees who rely on UNRWA, if it wasn’t able to. Israel has previously tried to dismantle the agency and called for the merging of its responsibilities with the UNHCR.

Aida Touma-Suleiman, an Israeli-Arab politician and member of the Arab-majority Hadash party, said the “bills stem from a long time ambition of the Israeli right – to strip Palestinian refugees from their status.”

“Israel is in effect creating new refugees every day while questioning the legitimacy of that very status,” Touma-Suleiman said on X.

What is the international community saying?

On Monday, foreign ministers of seven countries – Canada, Australia, France, Germany, Japan, South Korea and the United Kingdom – called on Israel to halt the legislation, expressing “grave concern” over its implications.

“UNRWA provides essential and life-saving humanitarian aid and basic services to Palestinian refugees in Gaza, East Jerusalem, the West Bank and throughout the region,” the foreign ministers said in a joint statement.

Despite its suspension of funding to UNRWA, the US has also opposed the ban. In a letter sent to two senior members of the Israeli government earlier this month, US Secretary of State Antony Blinken and US Defense Secretary Lloyd Austin said the Biden administration was “deeply concerned” about it.

This post appeared first on cnn.com

A Russian guided bomb attack on Kharkiv on Monday shattered much of the Derzhprom building, one of the most celebrated landmarks in Ukraine’s second city, dating from the 1920s.

Six people were injured in the 9 p.m. local time (3 p.m. ET) strike, adding to 13 wounded in an earlier overnight bomb attack on the city.

In the central Ukrainian city of Kryvyi Rih, a Russian missile struck a three-story residential building, killing one person and wounding at least 11.

President Volodymyr Zelensky denounced the strike on Kharkiv’s Derzhprom (State Industry) building, one of the most striking examples of Soviet-era constructivism architecture and dubbed the Soviet Union’s first skyscraper.

Writing on X, he also deplored the attack on Kryvyi Rih, his hometown, and called for renewed efforts to force Kremlin leader Vladimir Putin to halt the more than two-and-a-half-year-old war.

“Every handshake with war criminal Putin boosts his confidence. Every pleasant smile convinces him that he can get away with his crimes,” Zelensky wrote.

“Instead of cozying up to him, we must force him into peace through our collective decisiveness.”

Reuters news agency video showed parts of the Derzhprom building reduced to rubble and virtually all of its windows shattered.

“The occupiers have struck an iconic symbol of the city, known to all residents of Kharkiv,” Oleh Syniehubov, governor of the Kharkiv region, wrote on Telegram. He said several floors had been destroyed.

The Derzhprom building, placed on the “tentative” list of UNESCO World Heritage Sites, was completed in 1928 when Kharkiv was the capital of Soviet Ukraine.

The evening attack also hit a medical facility. Earlier strikes damaged an apartment building and storage space.

Eight were hurt in the city of Chuhuiv just to the southeast, Syniehubov said, an attack prosecutors said involved a multi rocket-launch system was used in Chuhuiv.

This post appeared first on cnn.com

A year after Shanghai’s boisterous Halloween celebrations made global headlines, revelers dressed as Republican presidential nominee Donald Trump and comic book superheroes were escorted away by police as authorities appeared to crack down on the festivities.

Videos on social media showed a heavy police presence in three busy Shanghai bar and restaurant areas, where partygoers typically celebrate the annual tradition more closely associated with the United States, raising concerns about further narrowing of personal freedoms in China.

Crowd control fences had been erected to restrict pedestrian traffic in some streets, according to images on social media, and a park near another popular nightlife area where costumed partygoers had congregated on Saturday was also shuttered the next day.

The tight controls in China’s most cosmopolitan city follow last year’s at times raucous celebrations, when young people came out in force to celebrate the first Halloween since the lifting of China’s stringent Covid-19 restrictions. Many donned costumes offering social critique – a rare phenomenon in a country where dissent is not tolerated in any form.

It was not clear whether they were detained or merely escorted from the immediate area. The circumstances leading up to these interactions with law enforcement were also not clear. As of Tuesday, some videos were still circulating China’s heavily censored internet, while others seemed to have been taken down.

While some officially sanctioned Halloween celebrations, such as those at Shanghai Disney Resort and the Happy Valley amusement park, went ahead as scheduled, the apparent tamp-down on some public Halloween gatherings this year caught the attention of Chinese social media users, with one user on Weibo, China’s equivalent of X, noting that her social media feed felt particularly empty.

Backlash against Western influence

Like other places in Asia, such as Japan and South Korea, many young people in China treat Halloween as an occasion to dress up and meet their friends in venues that put on themed events.

But Chinese state media have warned in recent years against citizens being “overly passionate” about Western festivals – part of a broader, nationalistic backlash against perceived foreign influence.

Last weekend’s celebrations appeared to end early for one young man who donned a blond wig and a bandage on his right ear to imitate former US President Donald Trump, a now-deleted post on Chinese social media platform Douyin showed. Trump wore the bandage after a bullet skimmed his ear during an assassination attempt in July.

Superheroes Spiderman and Batman, as well as a man who donned a yellow robe with a beaded necklace in the image of the Buddha, were all escorted away by police, according to online videos.

In China, crowd control measures are not unusual in public, especially during holidays, but some online users openly wondered what it would mean for future Halloweens.

“(I guess) there will never be any Halloween celebration in Shanghai as innovative as the one in 2023. It will slowly lose its edginess and become harmonized,” a user wrote.

Party like it’s 2023?

Celebrations last year in Shanghai were marked by huge crowds and revelers using the holiday to take tongue-in-cheek swipes at China’s strict Covid lockdowns and lackluster economy.

Some dressed as university graduates who had failed to land a job, a reference to China’s sluggish economy and high youth unemployment rates. Others rocked up in hazmat suits in a sarcastic swipe at China’s stringent Covid control measures, which saw Shanghai locked down for roughly two months and sparked rare protests.

That rare public critique in a country of heavy censorship both in online debate, media and entertainment was largely unimpeded by police last year, who practiced crowd control but did not appear to be proactively stopping people in costumes, based on media reports.

The Shanghai municipal government even praised last year’s Halloween celebration as “a sign of cultural tolerance.”

“The recent Halloween celebration in Shanghai, with its unique blend of western traditions and Chinese creativity, offered a glimpse into the evolving cultural landscape of a vibrant city,” it said in a statement last year.

Alfred Wu, an associate professor at the Lee Kuan Yew School of Public Policy at the National University of Singapore, said last year’s celebration happened during “a vacuum” when the Shanghai authorities were working to return to normal less than a year after the lifting of Covid lockdowns.

“This year authorities are much more prepared, and they do not agree with these kinds of activities,” he said.

This post appeared first on cnn.com

North Korean soldiers may be being readied for a move to the front lines of Russia’s war against Ukraine after being taught basic Russian commands, South Korean lawmakers told news agency Yonhap on Tuesday, citing the country’s intelligence officials.

About 10,000 North Korean soldiers are receiving military training in eastern Russia, the Pentagon estimated on Monday – up from a previous estimate of 3,000 by the White House.

South Korea’s National Intelligence Service (NIS) is now watching for the possibility of “some North Korean personnel, including high-ranking military officials, moving to the front lines,” said lawmakers Lee Seong-kweun and Park Sun-won, who were briefed by the NIS during a closed-door meeting of a parliamentary intelligence committee.

Russia is teaching North Korean soldiers about 100 basic military words like “fire” and “in position,” the lawmakers told Yonhap.

However, they added, it’s clear that North Korean soldiers are struggling to communicate – and it’s not clear whether they’ll be able to bridge the language gap.

North Korea has also stepped up its security measures – both to protect its dictator Kim Jong Un and to prevent news of the North Korean deployments to Russia from spreading within the highly isolated, impoverished country.

To this end, North Korean officers involved in the Russian effort are banned from using phones, while families of soldiers are told that their loved ones are simply participating in a “military exercise,” the lawmakers told Yonhap.

Despite these measures, word has spread within North Korea of deployments to Russia – sparking “unrest” in some parts of the country, the lawmakers said, according to Yonhap.

Some residents and soldiers have voiced fears of possibly being sent to Russia themselves, while others have questioned why they are being sacrificed for a different country, Yonhap reported.

Last week, Ukraine intercepted Russian transmission channels and released audio, with Russian soldiers heard talking disdainfully about the incoming North Korean soldiers, calling them the “K Battalion” and referring to them as “the f**king Chinese.”

The intercepts also reveal plans to have one interpreter and three senior officers for every 30 North Korean men, which the Russian soldiers are heard in the audio condemning.

“The only thing I don’t understand is that there [should be] three senior officers for 30 people. Where do we get them? We’ll have to pull them out,” one Russian serviceman says.

This could mark the first time North Korea makes a significant intervention in an international conflict. North Korea has one of the world’s largest militaries with 1.2 million soldiers, but most of its troops lack combat experience.

The Kremlin had initially dismissed allegations of North Korean troop deployments, but at the BRICS summit in Russia last week, President Vladimir Putin did not deny that Pyongyang had sent soldiers to the country.

North Korea said on Friday that any troop deployment to Russia to aid the war in Ukraine would conform with international law, state media reported, without explicitly confirming such presence. North Korea had previously dismissed such reports.

North Korean Foreign Minister Choe Son Hui is now in Russia for her second trip there in six weeks, having departed Pyongyang on Monday. She likely traveled to discuss potentially dispatching more North Korean troops – and what Pyongyang would receive in return, the lawmakers told Yonhap.

The news also comes as South Korea’s foreign and defense ministers head to Washington to speak with their counterparts, Secretary of State Antony Blinken and Defense Secretary Lloyd Austin, for an annual ministerial meeting.

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A paedophile who made thousands of pounds by creating child abuse images using AI and real pictures of children has been jailed for 18 years in a landmark case.

Hugh Nelson used a 3D character generator to turn ordinary, non-explicit pictures of children into child abuse images, before selling them on an internet forum used by artists.

People who knew the children in the real world would send the 27-year-old images of them.

Nelson, from Bolton, would then charge his network of paedophiles £80 for a new “character”. After that, it was £10 per image to animate them in different, explicit positions.

Over an 18-month period, Nelson admits he made around £5,000 from selling these images.

In some cases, Nelson then went on to encourage his clients to rape and sexually assault the children, the court heard.

In a police interview, the paedophile told officers: “A lot of my characters were commissioned by their dads, uncles, family friends.”

Jeanette Smith, a specialist prosecutor for the CPS, said: “This is one of the first cases of its kind that demonstrates a link between people like Nelson, who are creating computer-generated images using technology, and the real-life offending that goes on behind that.”

A number of paedophiles have been sent to prison recently for using AI to create child abuse images.

In Nelson’s case, however, police were able to link the images he generated to real children for the first time.

Nelson, who had no previous convictions, was arrested at his family home in Egerton, Bolton, in June last year and told police he had a sexual interest mainly in girls aged about 12.

The children who he was sent pictures of were all based abroad, in France, Italy and the United States.

Police officers in those countries have been passed information about Nelson’s offending, and more arrests have been made.

Although this is the first time someone has been prosecuted for creating this kind of child abuse imagery, the authorities are preparing for many more.

Inside the Internet Watch Foundation in Cambridge, dozens of analysts scour the internet every day, hunting down child abuse images and removing them from the internet.

In the last six months, they’ve seen more child abuse images made using AI than they did all of last year.

Dan Sexton, the charity’s chief technical officer, said: “Our work has always been difficult anyway.

“[But] we’ve never had to deal with the possibility that someone could download some software on their computer and create an infinite amount of new images.

“They use as many as they can until the hard drives fill up. That’s a new type of harm that which we have not been prepared for.”

One of the charity’s analysts, known only as Jeff when he’s at work to protect his identity, said he was worried about how convincing AI imagery is becoming.

“We’re reaching the point now where even a trained analyst would struggle to see whether it was real or not,” he said.

In August, Nelson pleaded guilty at Bolton Crown Court to 11 offences, including three counts of encouraging the rape of a child under 13, one count of attempting to incite a boy under 16 to engage in a sexual act, three counts each of the distribution and making of indecent images, and one count of possessing prohibited images.

At an earlier court appearance in July 2023, he also pleaded guilty to four counts of distributing indecent pseudo photographs of children and one of publishing an obscene article.

Detective Constable Carly Baines, from Greater Manchester Police, said the case was “deeply horrifying”.

She added: “It became clear to us after extensive trawls of his many devices by digital forensic experts however, that his behaviour went far beyond what clearly he was seeing as a ‘business opportunity’.

“Not only was he creating and selling these images, but he was engaging in depraved sexualised chat online about children and going as far as to encourage people interested in his online content to commit contact offences such as rape against children they knew or were related to.”

This post appeared first on sky.com

An AI-replicated Sir Michael Parkinson is set to host a new podcast, featuring a series of completely unscripted interviews with celebrities.

Virtually Parkinson is a world-first podcast according to its producers, Deep Fusion Films, and has been made with the support and involvement of Parkinson’s family and estate.

Known for his interviews with the world’s biggest stars, Parkinson died last year aged 88, following a brief illness.

The eight-part show will use AI technology to synthetically recreate the late presenter’s voice and interview style, drawing from a back catalogue of over 2,000 of his interviews.

The system – dubbed “Squark” – uses AI tools to allow live humans to speak with voices from the past.

Calling it “a tribute to my Dad,” Parkinson’s son, Mike Parkinson, reached out to the company with the idea of creating the podcast, as a way to preserve his father’s legacy.

He said: “I want audiences to marvel at the technology, the cleverness and cheekiness of the concept, but mostly I want them to remember just how good he was at interviewing and enjoy the nostalgia and happy memories.

“Through this platform, his legacy can continue, entertaining a new generation of fans.”

Deep Fusion Films co-founder Jamie Anderson said watching Parkinson’s son’s reaction to hearing his late father’s voice was “something really special,” adding that those who had listened to the AI replication had been “wowed” by its accuracy and warmth.

The company has expanded to create the project, hiring a new head of creative AI, an AI prompt engineer, researchers, guest bookers, podcast producers, and a sound engineer.

AI ethics in the spotlight

Concerns over the growing use of AI in the industry partly inspired last year’s US strike by actors and writers, which brought Hollywood to a virtual standstill.

In 2022, the UK acting union Equity launched a campaign called Stop AI Stealing The Show.

Performers have found their jobs particularly vulnerable to new technology, putting both their livelihoods and reputations at risk, in the case of deepfakes mistaken by the public as the real thing.

Touching on the ethics of the project, Deep Fusion Films says it is “openly showcasing the AI aspect,” and will signpost that the podcast is hosted by AI at the start.

It will also feature a debrief with the interviewee about what it was like to be interviewed by an AI at the end.

Guests are yet to be confirmed, but are said to be “notable people from a variety of spheres” including film and TV, music, and politics.

Born into a family of miners in Barnsley, Parkinson’s broadcasting career saw him front more than 600 shows and 2,000 interviews, working with the BBC, ITV, and Sky.

He interviewed stars including John Wayne, Fred Astaire, John Lennon, Tom Cruise, Madonna, and the Beckhams, plus a notably prickly interview with Hollywood star Meg Ryan.

Virtually Parkinson will be released on the official Michael Parkinson YouTube channel later this year, alongside a curated collection of archival footage.

This post appeared first on sky.com

People who hear bullying or abusive voices could find peace with the help of therapy using computer-generated avatars, according to new research.

The digital animations are created by people with psychosis to fit the voices they hear.

They then role-play with the avatar under the guidance of a therapist, learning to push back against their tormentor.

A study by clinical psychologists at Kings College London (KCL) shows just a few sessions of avatar therapy reduces both the distress and frequency of the voices.

Ruth spent more than five years in hospital because of her illness.

But after therapy with an avatar that she created, she’s now married and about to start a new job.

“When I hear the voices, I hear them as if they’re standing right behind me, hissing in my ear, making remarks,” she told Sky News.

She continued: “Sometimes they do a running commentary of everything I’m doing.

“And other times it’s like they are screaming and yelling directly into my ear. It can be exhausting.

“When I first started with the avatar it was pretty brutal at times, the stuff it would say.

“But over time, I learned that I could overpower that voice.”

‘Face to face’

Therapy begins with people creating a digital avatar to represent the voices they hear.

They first select the right vocal sound for the avatar.

Then, in a process similar to building a police identikit image of a suspect, they choose facial features to create an image that fits the voice they hear.

During therapy, they have a conversation with the avatar, which is under the control of a clinical psychologist, learning to stand up to the distressing voices.

Dr Tom Ward, a clinical psychologist at KCL, said: “It’s typically a very powerful experience for the person.

“The voice is something that they might have been avoiding for many years, and they’re coming face to face with it so people can be understandably anxious.

“The job of the therapist is to make sure that it feels safe enough for them to interact with the avatar.”

‘Extremely important finding’

A study on 345 people, funded by the Wellcome Trust and published in the journal Nature, showed avatar therapy helped to push the voices into the background, allowing them to resume a more normal life.

Professor Philippa Garety, the lead researcher, said it was the first therapy shown to have a sustained impact on how often people hear voices.

“This is an extremely important finding,” she said.

“Hearing fewer voices, less often, or voices going away altogether can have a hugely positive impact on their day-to-day lives.”

NICE, the authority that regulates treatments on the NHS, has backed the therapy.

It will now be rolled out to clinics in England for more real-world testing.

This post appeared first on sky.com

A new radioactive therapy has shrunk a man’s deadly brain tumour by half, in what experts hope could be a breakthrough cancer treatment.

Paul Read, a 62-year-old engineer from Luton, noticed he had a severe headache last December. Two weeks later, his wife Pauline was concerned he had a stroke as his face appeared to have dropped on one side.

He was diagnosed with recurrent glioblastoma – a type of brain cancer which kills most patients within 18 months – after doctors found a large mass on his brain.

Despite undergoing an operation on 27 December, followed by courses of radiotherapy and chemotherapy, Mr Read was told in July his tumour was growing again.

“I was fully expecting the tumour to return due to its aggressive nature,” he said. “I know the outcome isn’t great and I was happy to explore anything else.”

He was then offered the chance to become the first patient in a clinical trial aiming to cure the disease, run by the University College London Hospitals NHS Foundation Trust (UCLH).

In the CITADEL-123 trial, surgeons remove as much tumour as possible before implanting a small medical device called an Ommaya reservoir under the scalp, which connects to the tumour via a small tube.

The nuclear medicine team at UCLH then inject a drug – ATT001, which helps repair DNA damage in cells – directly into the tumour to deliver small amounts of radioactivity.

The drug, given weekly for four to six weeks, causes lethal damage to tumour cells but leaves healthy tissue unaffected.

Since starting the experimental treatment, Mr Read has seen his tumour shrink by half in just a matter of weeks.

“This trial was a lifeline, as the likelihood of survival according to the data was a year or less for me,” he said.

“I am delighted to be given the opportunity to be part of this trial and I have not experienced any side effects from the injections.”

“I am feeling very good,” the engineer added. He also said he’s not afraid of the treatment failing to cure his cancer if it can help others.

“We are all dealt a hand of cards and you don’t know which ones you are going to get,” he said.

“It will be wonderful if this treatment helps me and if it doesn’t, it doesn’t.

“I am more than happy – even it if doesn’t benefit me, it may benefit someone else down the line. So I have got nothing to lose and everything to hope for.”

Dr Paul Mulholland, UCLH consultant medical oncologist who designed the trial, said the reduction of Mr Read’s tumour “is really quite remarkable for somebody whose tumour is so aggressive”.

“We have to aim to cure this disease,” he said. “Primary brain tumours do not metastasize around the body and generally stay in the same location in the brain.

“It doesn’t spread to the rest of the body, so using a targeted – directly into the tumour – approach makes sense.”

A second patient is currently undergoing the same procedure, with one being treated a month by the team, and Dr Mulholland said the trial aims to have up to 40 patients treated.

The dose of radiation will be increased throughout the trial and researchers plan to combine ATT001 with immunotherapy – which trains the body’s immune system to kill cancerous cells.

While he said early signs are promising, Dr Mulholland noted the trial is a “first-in-human study so we’ve been cautious in our approach and are only treating patients for six weeks”.

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The House Republicans’ campaign arm is confident that voter enthusiasm for former President Donald Trump will push them to victory in tight races across the country on Election Day.

A National Republican Congressional Committee (NRCC) memo being sent to candidates and campaigns Monday morning, obtained by Fox News Digital, said the House GOP would rise or fall with Trump.

‘The NRCC holds a Trump card as we enter the home stretch: a historic environmental advantage for the GOP with Donald Trump at the top of the ticket,’ it said. 

‘The House has not flipped in the opposite direction of the results of a presidential election since the 1800s. In the previous 75 years, the House majority has not changed hands during a presidential election cycle. It’s why less than two weeks from Election Day we believe House Republicans can grow our majority.’

It also argues that Trump’s momentum in districts that President Biden won in 2020 is greater than it was in the last election, citing internal data.

‘An October NRCC polling average shows that among the 16 Biden districts that House Republicans currently hold, Kamala only leads by less than a point on the ballot,’ the NRCC memo said.

‘This includes districts in blue states where Trump is currently either statistically tied or holds a lead where Biden won by double digits in 2020. In contrast, in 2020, Joe Biden won these 16 districts by more than 6.3% on average.’

A Fox News poll from mid-October found Trump leading Harris nationally 50% to 48%.

Fox News Digital reached out to House Democrats’ campaign mechanism, the Democratic Congressional Campaign Committee (DCCC), for comment.

Lawmakers running in tight races, generally known as ‘front-line’ candidates, traditionally must over-perform at the top of their ticket in presidential election years to win.

Both Democrats and Republicans have poured enormous time and resources into such races in New York and California, where a suburban backlash to cities’ progressive crime policies drove the House GOP into control in 2022.

There are 16 seats among that number where voters chose Biden over Trump in 2020; however, and the road to the House majority likely lies through them again.

Republicans’ optimism comes despite their fundraising lagging behind Democrats’ level since Vice President Kamala Harris became the party’s presidential nominee in July.

‘Despite Democrats’ fundraising advantage, Donald Trump’s popularity is pushing outgunned GOP challenger campaigns over the finish line,’ the memo said. 

‘Any Democrat-held seat won by Joe Biden by five points or less in 2020 is in danger of flipping to the GOP due to Trump’s surge – and in some areas of the country, that number is even higher.’

Democrats running in 25 of the 26 races dubbed by the nonpartisan Cook Political Report as ‘toss-ups’ have outraised their Republican opponents in the most recent three-month span, according to an analysis by The Hill.

Meanwhile, The DCCC raised $22.3 million in August, compared to $9.7 million by the NRCC. House Democrats ended that period with more cash than the GOP as well – $87 million compared to $70.7 million.

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