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— The Food and Drug Administration is phasing out an animal testing requirement for antibody therapies and other drugs in favor of testing on materials that mimic human organs, the FDA announced on Thursday. 

‘For too long, drug manufacturers have performed additional animal testing of drugs that have data in broad human use internationally. This initiative marks a paradigm shift in drug evaluation and holds promise to accelerate cures and meaningful treatments for Americans while reducing animal use,’ FDA Commissioner Martin A. Makary, said in comment provided to Fox News Digital. 

 ‘By leveraging AI-based computational modeling, human organ model-based lab testing, and real-world human data, we can get safer treatments to patients faster and more reliably, while also reducing R&D costs and drug prices. It is a win-win for public health and ethics.’ 

The phase-out focuses on ending animal testing in regard to researching monoclonal antibody therapies, which are lab-made proteins meant to stimulate the immune system to fight diseases such as cancer, as well as other drugs, according to the press release. 

Instead, the FDA will encourage testing on ‘organoids,’ which are artificially grown masses of cells, according to the FDA’s press release obtained by Fox Digital. 

‘The FDA will promote the use of lab-grown human ‘organoids’ and organ-on-a-chip systems that mimic human organs – such as liver, heart, and immune organs – to test drug safety. These experiments can reveal toxic effects that could easily go undetected in animals, providing a more direct window into human responses,’ the press release says. 

The FDA will also encourage the use of AI while testing drugs, including building computer modeling that can predict a drug’s behavior, Fox Digital learned. 

The phase-out will include updating its guidelines to recognize research conducted on organoids and through AI.

‘Companies that submit strong safety data from non-animal tests may receive streamlined review, as the need for certain animal studies is eliminated, which would incentivize investment in modernized testing platforms,’ the FDA explained in its press release. 

The FDA is slated to also work with fellow federal agencies, such as the National Institutes of Health, the National Toxicology Program and the Department of Veterans Affairs, to ‘accelerate the validation’ of the new testing standards and will hold a public workshop later this year to further discuss the matter. 

‘For patients, it means a more efficient pipeline for novel treatments. It also means an added margin of safety, since human-based test systems may better predict real-world outcomes. For animal welfare, it represents a major step toward ending the use of laboratory animals in drug testing. Thousands of animals, including dogs and primates, could eventually be spared each year as these new methods take root,’ Makary said. 

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A Mexican drug lord was released from custody after being convicted in the 1985 killing of Drug Enforcement Administration agent Enrique ‘Kiki’ Camarena. 

Ernesto ‘Don Neto’ Fonseca Carrillo, one of the co-founders of the Guadalajara Cartel, was freed last weekend after completing his 40-year sentence, a federal agent confirmed to the Associated Press. 

Fonseca, 94, had been serving the remainder of his sentence under home confinement outside Mexico City since being moved from prison in 2016. The DEA did not immediately respond to a request for comment Thursday from Fox News Digital. 

Rafael Caro Quintero, another Guadalajara Cartel co-founder who also was convicted in the murder, was one of 29 cartel figures Mexico sent to the United States in February. It’s unclear if the U.S. is now looking to bring Fonseca into custody. 

At the time of his murder, the DEA and Camarena had been utilizing a series of wiretaps to make sizeable drug busts inside Mexico. 

In February 1985, as Camarena left to meet his wife for lunch outside the U.S. consulate in Guadalajara, he was surrounded by officers from the DFS, a Mexican intelligence agency that no longer exists. 

‘Back in the middle 1980s, the DFS, their main role was to protect the drug lords,’ former DEA agent Hector Berrellez, who led the investigation into Camarena’s murder, told Fox News in 2013. 

The DFS agents then took Camarena, blindfolded and held at gunpoint, to one of Caro Quintero’s haciendas nearby. 

For more than 30 hours, Caro-Quintero and others interrogated Camarena and crushed his skull, jaw, nose and cheekbones with a tire iron. They broke his ribs, drilled a hole in his head and tortured him with a cattle prod. As Camarena lay dying, Caro-Quintero ordered a cartel doctor to keep the U.S. agent alive. 

The 37-year-old’s body was found dumped on a nearby ranch about a month later. 

In 2013, Caro Quintero walked free after serving 28 years in prison.  He was released after a court overturned his 40-year sentence for the kidnapping and killing of Camarena. 

Caro Quintero was arrested again by Mexican forces in July 2022 after he allegedly returned to drug trafficking. 

Fox News’ Greg Wehner, William La Jeunesse, Lee Ross and the Associated Press contributed to this report. 

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A 2022 Defense Department report long withheld by the Biden administration has recently surfaced and reveals that seven U.S. service members showed COVID-19-like symptoms after having competed in the World Military Games in Wuhan, China, months before the deadly virus first broke out in the U.S.

The explosive disclosure suggests that the virus was circulating in Wuhan months before China disclosed it to the world in December 2019. The games took place in October 2019, two months earlier. 

It also challenges the Biden administration’s public claims in 2021 that there was no evidence that any American participants contracted the virus at those games. The CIA, FBI and Energy Department have all now suggested that the COVID-19 virus pandemic may have originated via a lab leak from the city’s Wuhan Institute of Virology.

The 2022 report was legally required to be released publicly online more than two years ago ‘in a searchable format,’ but it only became available some time in late March, when the Trump administration uploaded it to a Defense Department website, The Washington Free Beacon reported. 

The outlet reported that the Biden administration did send copies of the report to the House and Senate Armed Services Committees in December 2022, but the report was never made available online by the administration. 

The report found that of the 263 U.S. delegation that traveled to the event, seven U.S. members showed COVID-19-like symptoms between Oct. 18, 2019 and Jan. 21, 2020. All symptoms were resolved within six days and could be attributed to other respiratory illnesses​.

The report also found that there were no significant outbreaks of COVID-19-like symptoms at Defense Department facilities after the athletes returned, although service members were not tested for COVID-19 or antibodies as testing was not available at that early stage of the pandemic.

However, Washington was one of the earliest states to show a spike in COVID-19, and the U.S. team used chartered flights to and from the games via Seattle-Tacoma International Airport, Prospect reported.

Then-Pentagon spokesperson John Kirby told the Washington Post in June 2021 that the military had ‘no knowledge’ of any COVID-19 infections among the troops that participated in those games.

The Pentagon, during Trump’s first term, said in June 2020 that there was no reason to test members as the event was held ‘prior to the reported outbreak,’ Prospect reported. 

Other international athletes reported having come down with COVID-19-like symptoms, the Daily Mail reported in June 2021. 

The games have long been suspected as being a ‘super spreader’ event which took place close to the Wuhan Institute of Virology. The U.S.-based EcoHealth Alliance, partially funded by the U.S. National Institutes of Health was conducting gain of function research there. 

‘Many of the athletes said ​Wuhan looked like a ‘ghost town’ in October‚ two months before China reported the first case of coronavirus there,’ the New York Post reported.

Former Rep. Mike Gallagher, R-Wis., in 2021 said that those months were critical and could have helped the United States understand the disease and ‘shut down travel earlier in order to stop the spread and ultimately save potentially millions of lives.’

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China has been ramping up its military actions around Taiwan in what one top commander warned on Thursday are not just drills, but ‘rehearsals.’

‘China’s unprecedented aggression and military modernization poses a serious threat to the homeland, our allies and our partners,’ Adm. Samuel Paparo, commander of the U.S. Indo-Pacific Command, said during a hearing with the Senate Armed Services Committee on Thursday. ‘With military pressure against Taiwan increasing by 300%, China’s increasingly aggressive actions near Taiwan are not just exercises, they are rehearsals.’

Beijing has long looked to assert its dominance over Taiwan as it aims to ‘reunify’ the island with mainland China in a move the West and Taipei have warned is against Taiwan’s wishes and would disturb the region’s status quo.

Taiwan identifies as a sovereign nation. However, it is officially recognized by China, the United Nations and the U.S. as part of the ‘One China’ policy – though the U.S. has increasingly warned Beijing against disrupting regional stability by forcibly ‘reunifying’ the island with the mainland. 

‘While the [People’s Liberation Army] PLA attempts to intimidate the people of Taiwan and demonstrate coercive capabilities, these actions are backfiring, drawing increased global attention and accelerating Taiwan’s own defense preparations,’ Paparo said. 

But it is not only China’s military posture toward Taiwan that concerns top military commanders. 

‘China’s outproducing the United States in air missile, maritime and space capability and accelerating these,’ Paparo said. ‘I remain confident in our deterrence posture, but the trajectory must change.’

The Indo-Pacific commander warned that China is outstripping the U.S. in the production of fighters at a rate of 1.2 to 1, and warned that the U.S. is falling behind when it comes to shipbuilding, as well as some missile and space-based capabilities. 

‘They built combatants at the rate of 6 to 1.8 to the United States,’ Paparo told the lawmakers, in reference to China’s investment in producing ships, aircraft and weaponry. 

‘We’ve got to get at the problems of why we don’t have enough [of a] combat logistics force – and that’s shipbuilding. Why we don’t have enough labor,’ Paparo said. ‘And those are looking hard at pay and incentives in order to recruit and retain those people.’

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Secretary of Defense Pete Hegseth quipped that the Trump administration has wiped out ‘99.9%’ of diversity, equity, and inclusion initiatives (DEI) from the military during a Cabinet meeting on Thursday. 

President Donald Trump questioned Hegseth about whether the military had eradicated 100% of DEI efforts under his leadership, as Cabinet members shared updates on their own agencies’ attempts to purge such policies. 

‘99.9, sir – I’m going to get that last point,’ Hegseth said. 

The Trump administration has unveiled multiple initiatives to curb DEI initiatives within the military, including signing an executive order in January barring transgender people from enlisting and serving openly in the military. 

However, two federal judges issued nationwide injunctions in March blocking the Trump administration from enforcing the ban while the lawsuit is pending. In a judgment rendered on March 19, U.S. District Judge Ana Reyes of Washington, D.C., said the Trump administration’s order was ‘soaked in animus,’ and discriminated based on a person’s transgender status.

‘Indeed, the cruel irony is that thousands of transgender servicemembers have sacrificed – some risking their lives – to ensure for others the very equal protection rights the Military Ban seeks to deny them,’ Reyes wrote in the decision.

Trump signed another executive order in January banning DEI content in K–12 schools that receive federal funds. While military service academies were originally exempt since they are not classified as K–12 institutions, the Pentagon issued instructions to the Naval Academy to remove DEI-related books from its library in March. 

Included in the list of nearly 400 books purged are ‘How to be Anti-Racist’ and ‘Stamped From the Beginning: The Definitive History of Racist Ideas in America’ by Ibram X. Kendi, as well as ‘Our Time is Now: Power, Purpose, and the Fight for a Fair America,’ by former Georgia Rep. Stacey Abrams.

Kendi is the founding director emeritus of the Boston University Center for Antiracist Research. He rose to national prominence following the 2020 death of George Floyd at the hands of Minneapolis police.

Hegseth has made clear that the Pentagon will not tolerate any DEI initiatives under his watch. 

‘The President’s guidance (lawful orders) is clear: No more DEI at @DeptofDefense,’ Hegseth said in a post on X, formerly Twitter, in January. ‘The Pentagon will comply, immediately. No exceptions, name-changes, or delays.’ 

The Associated Press contributed to this report. 

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U.S. Ambassador to Ukraine Bridget Brink is stepping down, the State Department confirmed Thursday, as the Trump administration ramps up its efforts to broker a peace deal between Russia and Ukraine.

Tammy Bruce, a State Department spokesperson, said Brink would be leaving her role, though she didn’t give a specific departure date. 

The news comes at a critical moment for U.S. foreign policy as officials work to ease tensions and end the grinding war in Eastern Europe.

Brink, a career diplomat with decades of experience, was nominated by then-President Joe Biden and unanimously confirmed by the Senate in May 2022, just months after Russia launched its full-scale invasion of Ukraine. 

She became the first U.S. ambassador to serve in Kyiv since 2019, helping reestablish America’s diplomatic presence after embassy staff were evacuated in the early days of the war.

Before serving in Ukraine, Brink was the U.S. ambassador to Slovakia and worked in top roles at the National Security Council. She speaks Russian and is known for strongly defending U.S. interests in Eastern Europe.

While in Ukraine, Brink was a vocal supporter of American military aid and often appeared publicly with Ukrainian leaders. Her resignation comes as the Trump administration shifts focus toward ending the war through diplomacy and renewed talks with Russia.

Also on Thursday, U.S. and Russian officials held rare face-to-face talks in Istanbul aimed at repairing long-strained diplomatic relations. The State Department said the two sides exchanged formal notes to finalize an agreement that would stabilize banking services for each country’s embassies, a step seen as key to keeping diplomatic missions operational.

In recent years, both countries have imposed financial restrictions on each other’s embassies and slashed staffing due to the fallout from the war. A finalized banking deal could open the door to restoring some of those lost diplomatic connections.

The State Department said follow-up talks are expected, though no date has been set.

Brink’s departure lands at a moment of major transition in U.S. foreign policy. Her exit may also clear the way for a new ambassador more closely aligned with the Trump administration’s push for a ceasefire deal.

The State Department did not immediately respond to Fox News Digital’s request for comment.

The Associated Press contributed to this report.

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The Senate has voted to confirm the general who told President Donald Trump that ISIS could be eradicated ‘very quickly’ with loosened rules of engagement during his first term to the role of chairman of the Joint Chiefs. 

The vote came in the wee hours of Friday morning after Democrats rejected a GOP attempt to quickly confirm Caine on Thursday and get out of town.

The vote tally was 60 to 25, with 15 Democrats supporting the Trump nominee.

An Air Force F-16 pilot by background, Caine will be the first National Guard general to be chairman of the Joint Chiefs. Trump plucked him from retirement to reactivate and serve as his top military advisor after firing Gen. C.Q. Brown in February. 

Brown had been behind a 2022 memo laying out diversity goals for the Air Force.  

Caine will be the first Joint Chiefs chairman who was not a four-star and the first to come out of retirement to fill the role. He hasn’t been a combatant commander or service chief, meaning Trump had to grant him a waiver to serve in the role. 

Caine acknowledged his unconventional nomination during a hearing before the Senate Armed Services Committee: ‘In our family, we serve. When asked, we always say yes. Senators, I acknowledge that I’m an unconventional nominee. These are unconventional times.’ ​

He worked as the associate director of military affairs for the CIA from 2021 to 2024 and founded a regional airline in Texas. He was a White House fellow at the Agriculture Department and a counterterrorism specialist on the White House’s Homeland Security Council.

Caine was among a group of military leaders who met with the president in December 2018 at the Al Asad airbase in Iraq. Trump was there to deliver a Christmas message and hear from commanders on the ground, and there Caine told Trump they could defeat ISIS quickly with a surge of resources and a lifting of restrictions on engagement. 

”We’re only hitting them from a temporary base in Syria,” Trump said Caine told him. ”But if you gave us permission, we could hit them from the back, from the side, from all over – from the base that you’re right on, right now, sir. They won’t know what the hell hit them.” 

Trump had claimed Caine was wearing a red MAGA hat the first time he met him – a claim Caine repeatedly denied during the hearing.

‘Sir, for 34 years, I’ve upheld my oath of office and my commitment to my commission, and I have never worn any political merchandise,’ Caine told Armed Services Chairman Roger Wicker, R-Miss. 

Trump, when he picked Caine, praised him as ‘an accomplished pilot, national security expert, successful entrepreneur, and a ‘warfighter’ with significant interagency and special operations experience.’

Caine vowed his duty would be to advise the president on defense considerations without any political influence. 

The role, he said, ‘starts with being a good example from the top and making sure that we are nonpartisan and apolitical and speaking the truth to power,’ Caine said.

Trump’s first chairman of the Joint Chiefs, Gen. Mark Milley, has now become a top foe – the president recently stripped him of his security clearance and had his portrait taken down at the Pentagon. 

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El Salvador says it shares intelligence with the United States about gang members wanted by the Central American nation and provides “complete records” on them before formally requesting their deportation.

Villatoro’s comments come after the Trump administration deported more than 270 men to El Salvador, accusing them of being members of the Venezuelan Tren de Aragua gang or Salvadorans tied to the MS-13 gang.

US officials later admitted that one of those deported – Kilmar Armando Abrego Garcia, a Maryland-based sheet metal worker and father of three – was removed from the US in an “administrative error.” He is now in El Salvador’s notorious high security prison Cecot, despite a 2019 ruling by an immigration judge that was meant to protect him from deportation due to death threats from a gang targeting his family’s pupusa business.

The case has sparked a broad debate over due process in the deportations. While the Trump administration has alleged Garcia Abrego was a member of MS-13, his attorneys and family have rejected those claims and insist his detention is unjust.

The Salvadoran government has not commented on individual cases, including Abrego Garcia’s. But Villatoro said that Salvadorans deported from the US who are placed directly into the country’s prison system are those with pending criminal records in El Salvador.

“We checked all of them. And if we found someone who we are very sure that he is a member of any gang in El Salvador, we capture them and put them in jail,” he said.

He also addressed cases where individuals claim innocence, saying: “It’s very common that some people say, ‘Oh, he’s innocent.’ But the problem is: your background talks for you, right? You can say, ‘I’m not a member’ — OK, but what happened with your criminal record?”

‘Vague accusations’

Abrego Garcia’s legal team has flatly rejected that claim.

“The government of El Salvador has not provided any convictions or substantiated evidence to support its claims, and it is deeply concerning that these unverified allegations are being used to retroactively justify a deportation that violated court orders,” the statement continued.

The Supreme Court on Monday temporarily paused a court-imposed midnight deadline to return Abrego Garcia to the US, agreeing to a request from President Donald Trump that will give the justices more time to consider the case.

It’s unclear what is influencing the US decision to block his return.

Villatoro insisted that El Salvador actively shares its information with US law enforcement and that deportations are based on detailed records.

He said the country has kept extensive files on suspected gang members for years, including those believed to be living in the US and elsewhere.

“We know their background — how many times they were captured for homicide, for drugs, for weapons,” he said. “This is not about random deportations — this is based on the full record.”

Villatoro, who has served in President Nayib Bukele’s cabinet since the beginning of his term, is considered one of the architects of his country’s anti-gang strategy.

The Cecot jail where Abrego Garcia is being held houses both convicted criminals and those still going through El Salvador’s court system.

With constitutional rights suspended under El Salvador’s yearslong state of emergency, some innocent people have been detained by mistake, Salvadoran president Bukele previously admitted. Several thousand of them have already been released.

Last year, the prison director estimated the inmate population was between 10,000 and 20,000. He now says it’s approaching the prison’s 40,000-inmate maximum — but declined to provide a specific figure, citing security concerns.

Villatoro said the government is prepared to expand the facility, or even construct a second Cecot-like maximum-security prison, if needed.

“We have enough land to build even another (Cecot),” he said.

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What was supposed to be a historic, era-defining trade war launched by US President Donald Trump against a range of countries has, for now, narrowed in on a singular target: China.

On Wednesday, Trump announced a three-month pause on all the “reciprocal” tariffs that had gone into effect hours earlier – with one exception, deepening a confrontation set to dismantle trade between the world’s two largest economies.

The pace of that escalation has been stunning. Over the course of a week, Trump’s tariffs on Chinese imports have jumped from 54% to 104% and now 125% – figures that add to existing levies imposed prior to the president’s second term. And China has retaliated in kind, raising additional, retaliatory duties on all US imports to 84%.

The showdown sets up an historic rupture that will not only cause pain for both of these deeply intertwined economies – but add tremendous friction to their geopolitical rivalry.

“This is probably the strongest indication we’ve seen pushing towards a hard decoupling,” said Nick Marro, principal economist for Asia at the Economist Intelligence Unit, referring to an outcome where the two economies have virtually no trade or mutual investment.

“It’s really hard to overstate the expected shocks this is going to have, not just to the Chinese economy itself, but also to the entire global trading landscape,” as well as on the US, he said.

Trump appeared to link his decision not to grant China the same reprieve as other nations to Beijing’s swift retaliation, telling reporters Wednesday that “China wants to make a deal, they just don’t know how quite to go about it.”

But the view from Beijing looks dramatically different.

Chinese leader Xi Jinping, China’s most powerful leader in decades, sees no option for his country to simply capitulate to what it calls America’s “unilateral bullying.” And he’s playing to his crowd. Publicly, Beijing has drummed up fervent nationalism around its retaliation – part of a strategy it’s been quietly preparing for more than four years since Trump was last in office.

While China has long said it wants to talk, Trump’s rapid escalation instead appears to have confirmed for Beijing that the US doesn’t. And in Xi’s calculation, observers say, China is prepared not just to fight back, but to use Trump’s trade turmoil to strengthen its own position.

“Xi has been very clear for a very long time that he expects China will enter a period of protracted struggle with the United States and its allies, that China needed to prepare for that, and they have quite extensively,” said Jacob Gunter, lead economy analyst at Berlin-based think tank MERICS.

“Xi Jinping has accepted that the gauntlet is thrown down, and they are ready to put up a fight.”

‘War of attrition’

Whether Trump would have suspended his so-called retaliatory tariffs on China alongside other nations had Beijing not moved so swiftly to retaliate remains an open question. Canada had retaliated but was included in the reprieve, which does not remove a 10% universal tariff imposed last week.

Regardless, Trump, who the White House described earlier this week as having a “spine of steel,” and Xi now appear locked in a war of attrition with the potential to upset a lopsided but highly integrated trade relationship worth roughly half a trillion dollars.

For decades, China has been the world’s factory floor, where increasingly automated and high-tech production chains churn out everything from household goods and shoes to electronics, raw materials for construction, appliances and solar panels.

Those factories satisfied the demand of American and global consumers for affordable goods but fueled an enormous trade deficit – and a feeling among some Americans, including Trump, that globalization has stolen US manufacturing and jobs.

Trump’s ratcheting up of tariffs to well over 125% could now cut China’s exports to the US by more than half in the coming years, by some estimates.

Many goods from China won’t be able to be quickly replaced – driving up US consumer prices, potentially for years, before new factories come online. That could ring up a tax hike for Americans of roughly $860 billion before substitutions, JP Morgan analysts said Wednesday.

In China, a wide swath of suppliers are likely to see their already narrow margins completely erased, with a new wave of efforts to establish factories in other countries set to begin.

The scale of the tariffs could lead to “millions of people becoming unemployed” and a “wave of bankruptcy” across China, according to Victor Shih, director of the University of California San Diego’s 21st Century China Center. Meanwhile, US exports to China could “go close to zero,” he added.

“But China can sustain that (situation) much more so than American politicians can,” he said.

That’s, in part, because China’s ruling Communist Party leaders do not face swift feedback from voters and opinions polls.

“During Covid they shut down the economy (causing) untold employment, suffering – no problem.”

Beijing too believes it can weather the storm.

“In response to US tariffs, we are prepared and have strategies. We have engaged in a trade war with the US for eight years, accumulating rich experience in these struggles,” a commentary on the front page of Communist Party mouthpiece People’s Daily said Monday.

It noted Beijing could take “extraordinary efforts” to boost domestic consumption, which has been persistently weak, and introduce other policy measures to support its economy. “The plans to respond are well-prepared and ample,” the commentary said.

And in the face of unknowns about how much further measures could escalate, voices from Beijing appear calm.

“The ultimate outcome hinges on who can withstand a longer ‘economic war of attrition,’” economist Cai Tongjuan of China’s Renmin University wrote in a state media op-ed earlier this week. “And China clearly holds a greater advantage in terms of strategic endurance.”

‘Preparing for this day’

Beijing in recent weeks has also been talking to countries from Europe to Southeast Asia in a bid to expand trade cooperation – and one up the US by winning over American allies and partners exasperated by the on-again-off-again trade war.

But it’s been bracing for US trade frictions since Trump’s first trade war and his campaign against Chinese tech champion Huawei, which were a wake-up call to Beijing that its economic rise could be derailed if it wasn’t prepared.

“The Chinese government have been preparing for this day for six years – they knew this was a possibility,” said Shih in California, who added that Beijing had supported countries to diversify supply chains and looked to manage some of its domestic economic challenges in preparation, among other efforts.

Today, China is much better placed to weather a broader trade conflict, experts say. Compared with 2018, it’s expanded its trade relations with the rest of the world, reducing the share of US exports from roughly one-fifth of its total to less than 15%.

Its manufacturers have also set up extensive operations in third countries like Vietnam and Cambodia, in part to take advantage of potentially lower US duties.

China has also built out its supply chains for rare earths and other critical minerals, upgraded its manufacturing technology with AI and humanoid robots and ramped up its advanced technology capabilities, including semiconductors. Since last year, the government has also worked, with varying success, to address issues like weak consumption and high local government debt.

“(China’s) weaknesses are significant, but in the context of an all-out brawl, these are manageable. The US is not going to be able to, on its own, bring China’s economy to the edge of destruction,” said Scott Kennedy, a senior adviser at the Center for Strategic and International Studies think tank in the US.

“As much as Washington doesn’t want to admit it, when China says you can’t contain China economically, they have a point.”

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Panama promotes itself “as the bridge of the world, heart of the universe” but lately the narrow Central American Isthmus and its namesake canal that joins the Atlantic to the Pacific have become the setting for a bitter clash between the world’s two preeminent economic superpowers.

The escalating war of words between the US and China over the canal has left Panama – which does not have a military – baffled and brings to mind the old proverb of how “when elephants fight, it is the grass that suffers.”

From the beginning of his second term, US President Donald Trump has claimed without proof that China secretly controls the canal where around 40% of US container traffic passes through. If China’s alleged influence over the canal wasn’t halted, Trump threatened to “take back” the iconic waterway that the US returned to Panama in 2000, employing military force if needed.

Panama’s President José Raúl Mulino rejects Trump’s claims but has also made significant efforts to placate the White House, such as dropping out of China’s Belt and Road investment initiative in February.

In March, US investment giant BlackRock announced a $22.8 billion deal to buy 43 ports, including two located on either side of the Panama Canal, from CK Hutchison, the Hong Kong logistics company that the Trump administration has accused of being under Beijing’s control – something Hutchison denies.

But those concessions seem to have only added fuel to the White House’s bellicose rhetoric, most recently this week from Secretary of Defense Pete Hegseth during a visit to Panama to attend the Central American Security Conference.

“I want to be very clear, China did not build this canal,” Hegseth said Tuesday. “China does not operate this canal and China will not weaponize this canal. “Together with Panama in the lead, we will keep the canal secure and available for all nations through the deterrent power of the strongest, most effective and most lethal fighting force in the world.”

Beijing angrily fired back at Hegseth’s verbal broadsides.

“Who represents the real threat to the canal? People will make their own judgment,” China’s government retorted.

Hegseth’s statements represented a shift – Panama was again a “partner” that, contrary to what Trump had said, “operates” the canal. Still, the defense secretary stopped short of saying publicly the canal belonged to Panama.

In fact, the Pentagon appeared to omit a key line to that effect from a joint statement, which in the Panamanian version reads, “Secretary Hegseth recognized the leadership and inalienable sovereignty of Panama over the Panama Canal and its adjacent areas.”

The discrepancy over the statement called into mind a similar puzzling episode in February where the State Department announced that Panama would waive tolls on US Navy ships going through the canal; Mulino the next day angrily denied his government had ever agreed to that.

But on Wednesday Panama’s Canal Affairs Minister José Ramón Icaza told reporters that the Panama Canal Authority agreed to find a “mechanism” that allows US Naval ships to pass through the canal at a “neutral cost” in exchange for security provided by those ships and the US recognizing Panamanian sovereignty over the canal.

Even though, according to Panama’s government, US Navy ships only spend on average a few million dollars each year crossing through the canal, the Trump administration had pushed hard for the concession from the Canal Authority which according to Panamanian law is supposed to charge all countries the same rates for crossings.

Mulino has proven to be a key ally on immigration to Washington. During the Biden administration, Mulino had already begun closing the Darien Gap, where hundreds of thousands had crossed on their way to the US and by accepting deportation flights from the US.

But there are clearly limits on which US demands he can accommodate, as his countrymen and much of the region grow exasperated by increasing saber rattling from Trump and demands for further concessions.

On Wednesday, at a news conference, Hegseth alluded to the possibility of reestablishing US military bases to guard the canal.

Minutes later, with Hegseth looking on, Panama’s Security Minister Frank Ábrego flatly denied that Mulino was considering the possibility of allowing US bases in the country.

It’s not clear if Trump will take “no” for an answer and as the US-China tug of war over the canal heats up, Panama is clearly feeling the strain.

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